Chronic wound is a common complication
for diabetic patients,
which
entails substantial inconvenience, persistent pain, and significant
economic burden to patients. However, current clinical treatments
for diabetic chronic wounds remain unsatisfactory. A prolonged but
ineffective inflammation phase in chronic wounds is the primary difference
between diabetic chronic wounds and normal wounds. Herein, we present
an effective antioxidative system (MOF/Gel) for chronic wound healing
of diabetic rats through integrating a metal organic framework (MOF)
nanozyme with antioxidant enzyme-like activity with a hydrogel (Gel).
MOF/Gel can continuously scavenge reactive oxygen species to modulate
the oxidative stress microenvironment in diabetic chronic wounds,
which leads to a natural transition from the inflammation phase to
the proliferation phase. Impressively, the efficacy of one-time-applied
MOF/Gel was comparable to that of the human epidermal growth factor
Gel, a widely used clinical drug for various wound treatments. Such
an effective, safe, and convenient MOF/Gel system can meet complex
clinical demands.