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Solvent Effects: Syntheses of 3,3-Difluorooxindoles and 3‑Fluorooxindoles from Hydrazonoindolin-2-one by Selectfluor

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journal contribution
posted on 16.05.2018, 00:00 authored by Qiong Yang, Guo-Li Dai, Yu-Ming Yang, Zhuangzhu Luo, Zhen-Yu Tang
Efficient syntheses of 3,3-difluorooxindoles and 3-fluorooxindoles via fluorination of hydrazonoindolin-2-one with Selectfluor are reported. Under different solvent conditions, this method produced 3,3-difluorooxindoles and 3-fluorooxindoles selectively. The broad substrate scope and mild reaction conditions make this transformation a valuable method in drug discovery and development.