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Solvent-Free, Continuous Synthesis of Hydrazone-Based Active Pharmaceutical Ingredients by Twin-Screw Extrusion

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journal contribution
posted on 05.08.2020, 12:12 by Deborah E. Crawford, Andrea Porcheddu, Aaron S. McCalmont, Francesco Delogu, Stuart L. James, Evelina Colacino
Twin-screw extrusion (TSE) was used to synthesize hydantoin-based active pharmaceutical ingredients (APIs) such as nitrofurantoin and dantrolene, employing minimal or no solvent. Postsynthetic workup was not required. This work demonstrates that solvent-free synthesis can be conducted in a continuous manner for pharmaceutical products.