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Solution Phase Combinatorial Synthesis of Biaryl Libraries Employing Heterogeneous Conditions for Catalysis and Isolation with Size Exclusion Chromatography for Purification

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journal contribution
posted on 16.03.1999, 00:00 by Dale L. Boger, Joel Goldberg, Carl-Magnus Andersson
A convenient and effective approach to the solution phase synthesis of biaryl libraries from iodoarenes is described enlisting 10% Pd−C as an inexpensive and readily available supported catalyst. Isolation and purification of small library mixtures, individual library members, and intermediates in the multistep sequence by a combination of liquid−liquid and liquid−solid extractions and size exclusion chromatography are detailed.