Solubility Determination and Correlation of Teflubenzuron in Four Cosolvent Mixtures

The equilibrium solubility of teflubenzuron in solvent mixtures of methanol (1) + water (2), ethanol (1) + water (2), propylene glycol (1, PG) + water (2), and N,N-dimethylformamide (1, DMF) + water (2) was determined experimentally by an isothermal dissolution equilibrium method within the temperature ranging from 278.15 to 323.15 K under an atmospheric pressure of 101.1 kPa. The solubility of teflubenzuron increased monotonously with the increase in mass fraction of methanol, ethanol, PG, and DMF and temperature. At the same temperature and mass fraction of methanol (ethanol, PG, and DMF), the mole fraction solubility of teflubenzuron is greater in DMF + water than in the other three solvent mixtures. Besides, the solubility of teflubenzuron was correlated with three models. The obtained average relative deviation (RAD) is lower than 0.41% for correlative studies. It is noteworthy that the solubility data presented in this work contributes to expansion of the physicochemical information about the solubility of drugs in binary solvent mixtures and also allows the thermodynamic analysis of the respective dissolution.