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Solubility Behavior and Synergistic Solvation Effects of N‑Benzylglycine in Eleven Neat and One Binary Solvent Systems from 283.15 to 323.15 K

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journal contribution
posted on 09.06.2021, 18:35 by Hui He, Jingxuan Qiu, Haishuang Huang, Ying Guo, Haoyou Liu, Shen Hu, Jiaming Han, Yue Zhao, Peng Wang
The equilibrium solubility of N-benzylglycine in 11 pure solvents (methanol, ethanol, n-propyl alcohol, isopropyl alcohol, n-butyl alcohol, acetone, acetonitrile, dichloromethane, ethyl acetate, 1,4-dioxane, and water) and one binary water + ethanol solvent mixture was measured by a static gravimetric method covering the temperature range of (283.15–323.15) K. The polymorphism of N-benzylglycine was characterized via the powder X-ray diffraction test and the results indicate that no crystal form transition occurred during the dissolution process in all solvents studied. When the solvent composition is constant, the solubility of N-benzylglycine in all neat solvents and solvent mixtures is positively correlated with the experimental temperature. With the increase of the mole fraction of water at a certain temperature, the solubility curve of the binary water + ethanol solvent mixtures shows an inflection point, which may be the result of the synergistic solvation effects. The KAT-LSER model equation was used to analyze the mixed solvent system by multiple linear regression analysis to reveal the interactions between solute–solvent and solvent–solvent. In addition, the modified Apelblat model and the Apelblat–Jouyban–Acree model were utilized to correlate the solubility data.