Solid-Phase Synthesis of
5-Biphenyl-2-yl-1H-tetrazoles

Kivrakidou, Olga; Bräse, Stefan; Hülshorst, Frank; Griebenow, Nils

doi:10.1021/ol0498848.s001

ol0498848_si_001.pdf (67.42 kB)

Solid-Phase Synthesis of 5-Biphenyl-2-yl-1H-tetrazoles

journal contribution

posted on 2004-04-01, 00:00 authored by Olga Kivrakidou, Stefan Bräse, Frank Hülshorst, Nils Griebenow

The combinatorial synthesis of novel biphenyl tetrazoles is described. Key steps include the simultaneous biphenyl formation and phenol deallylation under Suzuki cross-coupling conditions as well as the tetrazole ring formation on solid support. A representative library of 20 biphenyl tetrazoles was synthesized.