Solid-Phase Synthesis of 4(1H)-Quinolone and Pyrimidine Derivatives Based on a New ScaffoldPolymer-Bound Cyclic Malonic Acid Ester
journal contributionposted on 22.08.2002, 00:00 by Xian Huang, Zhanxiang Liu
An efficient method for the preparation of polymer-bound cyclic malonic acid ester starting from Merrifield resin has been developed. Reaction of the resin-bound cyclic malonic acid ester with triethyl orthoformate and subsequent double substitution with nucleophilic reagents, such as arylamine, urea, thiourea, 2-aminobenzothiazoles, or isothiosemicarbazones, afforded the corresponding polymer-bound substituted aminomethylene cyclic malonic acid esters, which upon thermal treament led to 4(1H)-quinolones, 3-substituted uracils and thiouracils, 4H-pyrimido[2,1-b]benzothiazol-4-ones, and 1-(N-alkylidene or benzylideneamino)-1,6-dihydro-2-methylthio-6-oxo-pyrimidines, depending on the structures of the nucleophilic reagents.
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alkylideneaminobenzothiazoleScaffoldnucleophilic reagentsEsterNewtreamenttriethyl orthoformateMerrifield resinbenzothiazolmethodSynthesiureaCyclicisothiosemicarbazonequinolonesubstitutionthiouracilarylaminebenzylideneaminopyrimidouracilPyrimidine DerivativesMalonicQuinolonepreparation4 Haminomethylene cyclic malonic acid estersthiourea