ol010102+_si_001.pdf (385.26 kB)
Download file

Solid-Phase Synthesis of 1,7-Disubstituted-1,3,5-triazepane-2,4-diones

Download (385.26 kB)
journal contribution
posted on 11.08.2001, 00:00 by Yongping Yu, John M. Ostresh, Richard A. Houghten
The solid-phase synthesis of 1,7-disubstituted-1,3,5-triazepane-2,4-diones from resin-bound amino acids is described. The exhaustive reduction of solid-support bound amides with borane afforded the requisite secondary amines, which following treatment with phenyl isocyanatoformate and cleavage, provided the corresponding triazepane-2,4-diones.