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Solid-Phase Enzymatic Synthesis of Oligonucleotides

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journal contribution
posted on 06.11.1999, 00:00 by Carole Schmitz, Manfred T. Reetz
The controlled and selective synthesis of oligonucleotides on the solid phase is possible under mild aqueous conditions using the enzyme T4 RNA ligase, the resins being tentagel or kieselguhr/polydimethylacrylamide.