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Download fileSlicing and Splicing of Bromodifluoro‑N‑arylacetamides: Dearomatization and Difunctionalization of Pyridines
journal contribution
posted on 2020-08-01, 15:29 authored by Hongtai Chen, Yanyan Yang, Lianxin Wang, Yuxiang Niu, Minjie Guo, Xiangwei Ren, Wentao Zhao, Xiangyang Tang, Guangwei WangCopper-catalyzed
dearomatization and difunctionalization of pyridines have been disclosed,
in which bromodifluoro-N-arylacetamide was sliced
into five fragments and three or four of them were transferred to
pyridine partners. Through this reaction, novel N-difluoromethyl-2-imine dihydropyridine derivatives can be conveniently
accessed from commercially available 4-amino substituted pyridines.
This strategy demonstrates a novel fluorination method featuring high
atom economy, environmental friendliness, an easily available catalyst,
and simple operation.