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Size-Dependent Tumor Penetration and in Vivo Efficacy of Monodisperse Drug–Silica Nanoconjugates
journal contribution
posted on 2016-02-19, 20:19 authored by Li Tang, Nathan
P. Gabrielson, Fatih M. Uckun, Timothy M. Fan, Jianjun ChengThe size of a nanomedicine strongly correlates with its
biodistribution,
tissue penetration, and cell uptake. However, there is limited understanding
how the size of nanomedicine impacts the overall antitumor efficacy.
We designed and synthesized camptothecin–silica nanoconjugates
(Cpt–NCs) with monodisperse particle sizes of 50 and 200 nm,
two representative sizes commonly used in drug delivery, and evaluated
their antitumor efficacy in murine tumor models. Our studies revealed
that the 50 nm Cpt–NC showed higher anticancer efficacy than
the larger analogue, due presumably to its faster cellular internalization
and more efficient tumor accumulation and penetration. Our findings
suggest that nanomedicine with smaller sizes holds great promise for
improved cancer therapy.