ol0c03653_si_001.pdf (19.24 MB)

Site-Selective Functionalization of 7‑Azaindoles via Carbene Transfer and Isolation of N‑Aromatic Zwitterions

Download (19.24 MB)
journal contribution
posted on 24.11.2020, 15:37 by Junheng Liu, Guangyang Xu, Shengbiao Tang, Qun Chen, Jiangtao Sun
The first systematic study on metal-carbene transfer reaction of 7-azaindoles has been conducted, and the unprecedented dearomative N7-alkylation reaction has been accomplished via ruthenium catalysis. Importantly, through a sequential dearomatization–aromatization process, an isolable, and new class of azaindole-based N-aromatic zwitterions has been discovered from the reaction of 7-azaindoles and diazoesters.