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Single Cell Transfection with Single Molecule Resolution Using a Synthetic Nanopore

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journal contribution
posted on 12.02.2014, 00:00 by Volker Kurz, Tetsuya Tanaka, Gregory Timp
We report the development of a single cell gene delivery system based on electroporation using a synthetic nanopore, that is not only highly specific and very efficient but also transfects with single molecule resolution at low voltage (1 V) with minimal perturbation to the cell. Such a system can be used to control gene expression with unprecedented precisionno other method offers such capabilities.