posted on 2023-11-24, 00:19authored byAlex M. Davies, Shrikant S. Londhe, Emma R. Smith, Jon A. Tunge
A photocatalytic methodology for the single step synthesis
of γ-ketoacids
from α-ketoacids has been developed. This method employs maleic
anhydrides as traceless synthetic equivalents of acrylic acids, achieving
a selective cross-coupling via a dual decarboxylative strategy, where
molecular CO2 is released as the only waste byproduct.
The method has also been expanded to incorporate a highly regioselective,
3-component coupling with various alcohols to access functionalized
γ-ketoesters.