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Simple and Efficient Protocol for the Synthesis of Functionalized Styrenes from 1,2-Dibromoethane and Arylboronic Acids

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journal contribution
posted on 11.07.2003, 00:00 by Vanusa R. Lando, Adriano L. Monteiro
A simple and efficient protocol for the preparation of functionalized styrenes is disclosed that employs the palladium-catalyzed cross-coupling reaction of arylboronic acids with vinyl bromide, generated in situ from 1,2-dibromoethane. The reaction is carried out under mild reaction conditions. Compared with the cross-coupling reactions usually employed to obtain vinylarenes, this protocol is very simple, overcomes the inconvenience of using of ethylene under pressure, and uses air-stable and widely available arylboronic acids instead of vinyl organometallic reagents.