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Silylative Carbocyclization of Allenyl-carbonyl Units with Et3SiH Catalyzed by Rhodium:  Cis-Stereoselective Synthesis of Homoallylic Cycloalkanols

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journal contribution
posted on 08.07.2003, 00:00 by Suk-Ku Kang, Young-Taek Hong, Joon-Hwan Lee, Won-Yeol Kim, Inhee Lee, Chan-Mo Yu
A new procedure for the synthesis of cis-2-triethylsilylvinyl-cyclopentanols and -cyclohexanols from allenyl-aldehydes and -ketones with Et3SiH through rhodium-catalyzed silylative carbocyclization is described. The use of Rh(acac)(CO)2 (1 mol %) to promote the reaction results in a mild and convenient protocol for the three-component assembly.