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Silver Effect in Regiodivergent Gold-Catalyzed Hydroaminations

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journal contribution
posted on 14.02.2019, 00:00 by Marcos Veguillas, Georgina M. Rosair, Magnus W. P. Bebbington, Ai-Lan Lee
We report a silver-induced switching of regioselectivity in gold-catalyzed reactions, and we provide mechanistic evidence to suggest a true “silver effect”: that is, one that is implicated in the catalytic process itself, via σ-gold π-silver acetylides. These results are of significance because they clearly show that the use of silver as halide abstractors in gold-catalyzed reactions may result in “silver effects” when terminal alkyne substrates are involved.