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Silver-Catalyzed Cycloisomerization of 1,n-Allenynamides

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journal contribution
posted on 2011-06-03, 00:00 authored by Pierre Garcia, Youssef Harrak, Lisa Diab, Pierre Cordier, Cyril Ollivier, Vincent Gandon, Max Malacria, Louis Fensterbank, Corinne Aubert
A variety of allenynamides can undergo cycloisomerization reactions in the presence of silver triflate thus leading to the formation of N-containing heterocycles incorporating cross-conjugated trienes. Access to new dienic 4-piperidinone and azepane motifs was achieved. An extension to one-pot tandem sequences involving silver-catalyzed cycloisomerization/Diels–Alder reaction was also examined.