American Chemical Society
ol7b00367_si_001.pdf (11.15 MB)

Silver-Catalyzed C(sp3)–H Chlorination

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journal contribution
posted on 2017-03-02, 23:29 authored by Jun Ozawa, Motomu Kanai
A silver-catalyzed chlorination of benzylic, tertiary, and secondary C­(sp3)–H bonds was developed. The reaction proceeded with as low as 0.2 mol % catalyst loading at room temperature under air atmosphere with synthetically useful functional group compatibility. The regioselectivity and reactivity tendencies suggest that the chlorination proceeded through a radical pathway, but an intermediate alkylsilver species cannot be ruled out.