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Silanediol-Catalyzed Chromenone Functionalization

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journal contribution
posted on 22.07.2016, 20:50 by Andrea M. Hardman-Baldwin, Michael D. Visco, Joshua M. Wieting, Charlotte Stern, Shin-ichi Kondo, Anita E. Mattson
Promising levels of enantiocontrol are observed in the silanediol-catalyzed addition of silyl ketene acetals to benzopyrylium triflates. This rare example of enantioselective, intermolecular chromenone functionalization with carbonyl-containing nucleophiles has potential applications in the synthesis of bioactive chromanones and tetrahydroxanthones.