ol6b01783_si_002.pdf (471.16 kB)
Silanediol-Catalyzed Chromenone Functionalization
journal contributionposted on 2016-07-22, 20:50 authored by Andrea M. Hardman-Baldwin, Michael D. Visco, Joshua M. Wieting, Charlotte Stern, Shin-ichi Kondo, Anita E. Mattson
Promising levels of enantiocontrol are observed in the silanediol-catalyzed addition of silyl ketene acetals to benzopyrylium triflates. This rare example of enantioselective, intermolecular chromenone functionalization with carbonyl-containing nucleophiles has potential applications in the synthesis of bioactive chromanones and tetrahydroxanthones.