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Short Total Synthesis of 8,10-Di-O-methylbergenin

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journal contribution
posted on 23.07.2002, 00:00 by Holger Herzner, Emma R. Palmacci, Peter H. Seeberger
A short, high-yielding synthesis of the C-glucoside 8,10-di-O-methylbergenin is reported. Key elements of the synthesis are a stereoselective installation of a β-C-aryl linkage, a palladium(0)-catalyzed aryl carbonylation, and a regioselective lactonization reaction. This pathway should allow access to a host of bergenin analogues.