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Short α/β-Peptides as Catalysts for Intra- and Intermolecular Aldol Reactions

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journal contribution
posted on 18.04.2008, 00:00 by Valerio D'Elia, Hans Zwicknagl, Oliver Reiser
Short α/β-peptides, containing conformationally restricted cis-β-aminocyclopropylcarboxylic acid units as turn-inducing elements, have been found to be efficient catalysts for inter- and intramolecular aldol reactions. The tripeptide H−(L)-Pro-▴-(L)-Pro−OH was identified to perform especially well in homogeneous and heterogeneous aqueous solutions as well as in organic solvents.