American Chemical Society
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Shishijimicins A−C, Novel Enediyne Antitumor Antibiotics from the Ascidian Didemnum proliferum

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journal contribution
posted on 2003-01-29, 00:00 authored by Naoya Oku, Shigeki Matsunaga, Nobuhiro Fusetani
Three new compounds of the enediyne antibiotics, shishijimicins A−C (13), have been isolated from the ascidian Didemnum proliferum. They encompass a novel sugar component, which is a conjugation product of a hexose and a β-carboline, attached to the calicheamicinone aglycone. Their structures have been determined by interpretation of spectral data. Shishijimicins showed extremely potent cytotoxicity against HeLa cells with IC50 values of 1.8−6.9 pM.