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Shear Stress and Its Effect on the Interaction of Myoblast Cells with Nanosized Drug Delivery Vehicles
journal contribution
posted on 2013-07-01, 00:00 authored by Leticia Hosta-Rigau, Brigitte StädlerAn important aspect to ensure progress
in biomedicine is the fundamental
understanding of the interaction of cells and tissue with (bio)materials.
The consideration of shear stress in drug delivery and/or tissue engineering
remains largely unexplored. To illustrate the fundamental relevance,
we employ a microfluidic setup to evaluate the myoblast cell response
to two prominent drug carrier systems, namely, liposomes and nanoparticles,
in the presence of low shear stress. We show that positively charged
carriers have an enhanced interaction with myoblast cells in the presence
of shear stress. This effect can be translated into improved therapeutic
response in terms of reduction in cell viability when delivering a
cytotoxic compound or into a better translocation efficiency when
using lipoplexes. Taken together, our fundamental findings open up
new possibilities in tissue engineering and drug delivery by considering
an additional parameter when delivering beneficial compounds.