posted on 2020-06-03, 12:37authored byXi Zhang, Hangying Xu, Jie Ning, Hui Ji, Junjie Yan, Yafei Zheng, Qingqing Xu, Chen Li, Liangcai Zhao, Hong Zheng, Hongchang Gao
Diabetes
mellitus (DM) can cause systemic metabolic disorders,
but the impact of gender on DM-related metabolic changes is rarely
reported. Herein, we analyzed metabolic alterations in the heart,
liver, and kidney of male and female mice from normal to diabetes
via a 1H NMR-based metabolomics method and aimed to investigate
sex-specific metabolic mechanisms underlying the onset and development
of diabetes and its complications. Our results demonstrate that male
mice had more significant metabolic disorders from normal to diabetes
than female mice. Moreover, the kidney was found as the major organ
of metabolic disorders during the development of diabetes, followed
by the liver and heart. These altered metabolites were mainly implicated
in energy metabolism as well as amino acid, choline, and nucleotide
metabolism. Therefore, this study suggests that the kidney is the
primary organ affected by diabetes in a sex-specific manner, which
provides a metabolic view on the pathogenesis of diabetic kidney diseases
between genders.