Seven-Membered Cyclic Sulfite Eudesmane Derivatives:  Partial Synthesis, Structural Determination, and Enzymatic Resolution

Two chromatographically inseparable, diastereomeric eudesmane cyclic sulfites have been semisynthesized from α-santonin. This diastereomeric mixture was resolved by enzymatic acetylation with CCL. Each cyclic sulfite derivative was individually characterized on the basis of its spectroscopic and crystallographic properties.