np050096g_si_001.pdf (950.36 kB)
Download fileSesquiterpenes from the Red Alga Laurencia tristicha
journal contribution
posted on 2005-06-24, 00:00 authored by Jie Sun, Dayong Shi, Ming Ma, Shuai Li, Sujuan Wang, Lijun Han, Yongchun Yang, Xiao Fan, Jiangong Shi, Lan HeSeven new sesquiterpenes (1−7), together with seven known sesquiterpenes, aplysin (8), aplysinol (9),
gossonorol (10), 7,10-epoxy-ar-bisabol-11-ol (11), 10-epi-7,10-epoxy-ar-bisabol-11-ol (12), johnstonol (13),
and laurebiphenyl (14), have been isolated from the red alga Laurencia tristicha. The structures of new
compounds were established as laur-11-en-2,10-diol (1), laur-11-en-10-ol (2), laur-11-en-1,10-diol (3),
4-bromo-1,10-epoxylaur-11-ene (4), cyclolauren-2-ol (5), laurentristich-4-ol (6), and ar-bisabol-9-en-7,11-diol (7) by means of spectroscopic methods including IR, HRMS, and 1D and 2D NMR techniques.
Compound 6 possessed a novel rearranged skeleton. All compounds were tested against several human
cancer cell lines including lung adenocarcinoma (A549), stomach cancer (BGC-823), hepatoma (Bel 7402),
colon cancer (HCT-8), and HELA cell lines. Laurebiphenyl (14) showed moderate cytotoxicity against all
tested cell lines, with IC50 values of 1.68, 1.22, 1.91, 1.77, and 1.61 μg/mL, respectively. Other compounds
were inactive (IC50 > 10 μg/mL).