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Sesquiterpene Lactones from Gonospermum gomerae and G. fruticosum and Their Cytotoxic Activities

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journal contribution
posted on 26.12.2008, 00:00 by Jorge Triana, José Luis Eiroa, Juan José Ortega, Francisco León, Ignacio Brouard, Fernando Torres, José Quintana, Francisco Estévez, Jaime Bermejo
Four new sesquiterpene lactones (14) and a new sesquiterpene (5) together with 20 known compounds were isolated from two Gonospermum species (G. gomerae Bolle and G. fruticosum Less). Their structures were determined by analysis of spectroscopic data, including 1D and 2D NMR. The cytotoxicity of several new and known natural and semisynthetic sesquiterpene lactones was also assessed against human myeloid leukemia cell lines (HL-60 and U937), human melanoma cells (SK-MEL-1), and human adenocarcinoma (A549).