Sequential Suzuki–Miyaura Coupling/Lewis Acid-Catalyzed Cyclization: An Entry
to Functionalized Cycloalkane-Fused Naphthalenes

Mahecha-Mahecha, Camilo; Lecornué, Frédéric; Akinari, Sumita; Charote, Thomas; Gamba-Sánchez, Diego; Ohwada, Tomohiko; Thibaudeau, Sébastien

doi:10.1021/acs.orglett.0c02020.s001

ol0c02020_si_001.pdf (10.7 MB)

Sequential Suzuki–Miyaura Coupling/Lewis Acid-Catalyzed Cyclization: An Entry to Functionalized Cycloalkane-Fused Naphthalenes

journal contribution

posted on 2020-08-05, 17:41 authored by Camilo Mahecha-Mahecha, Frédéric Lecornué, Sumita Akinari, Thomas Charote, Diego Gamba-Sánchez, Tomohiko Ohwada, Sébastien Thibaudeau

Functionalized angular cycloalkane-fused naphthalenes were prepared using a two-step process involving a Pd-catalyzed Suzuki–Miyaura coupling of aryl pinacol boronates and vinyl triflates followed by a boron trifluoride etherate-catalyzed cycloaromatization.