Sequential Rhodium-, Silver-, and Gold-Catalyzed Synthesis of Fused Dihydrofurans
journal contributionposted on 19.08.2011, 00:00 by Hengbin Wang, Justin R. Denton, Huw M. L. Davies
A triple cascade process was developed for the rapid synthesis of polycyclic benzo-fused dihydrofurans. The first step is a rhodium-catalyzed cyclopropanation of α-aryldiazoketones with alkenes. This is followed by a silver-catalyzed ring expansion to dihydrofurans, which then undergo a gold-catalyzed cyclization to form benzo-fused dihydrofurans.