Sequential Hydrozirconation/Cyclization of Dienes, a New Route toward Trans 2‑Substituted Vinylcyclopentanes

The diastereoselective synthesis of trans-2-substituted vinylcyclopentanes is described. The method is based on the intramolecular coupling of 7-methoxy-1,5-dienes involving a sequential activation of the CC double bonds via hydrozirconation and TMSOTf-promoted allylation.