posted on 2022-12-26, 15:34authored byAnchal Saxena, Nayan Ghosh
Cascade or domino reactions serve as a powerful technique
for the
synthesis of complex organic scaffolds in one pot. Herein, a Cu(II)-catalyzed
and silica gel-assisted multicomponent reaction (MCR) between bromoalkyne-tethered
cyclohexadienones, amides, and water for the construction of hexahydrobenzofuran-3-carboxamide
is developed. The reaction proceeds via a C–N coupling reaction
followed by hydrative cyclization of ynamide intermediates. Notably,
good to excellent diastereoselectivity is complementary of this reaction.