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Sensitized Aliphatic Fluorination Directed by Terpenoidal Enones: A “Visible Light” Approach

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journal contribution
posted on 02.01.2018, 00:00 by Desta Doro Bume, Stefan Andrew Harry, Cody Ross Pitts, Thomas Lectka
In our continued effort to address the challenges of selective sp3 C–H fluorination on complex molecules, we report a sensitized aliphatic fluorination directed by terpenoidal enones using catalytic benzil and visible light (white LEDs). This sensitized approach is mild, simple to set up, and an economical alternative to our previous protocol based on direct excitation using UV light in a specialized apparatus. Additionally, the amenability of this protocol to photochemical flow conditions and preliminary evidence for electron-transfer processes are highlighted.