American Chemical Society
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Self-Referencing Optofluidic Ring Resonator Sensor for Highly Sensitive Biomolecular Detection

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journal contribution
posted on 2013-10-01, 00:00 authored by Ming Li, Xiang Wu, Liying Liu, Xudong Fan, Lei Xu
The noise-suppression techniques of label-free optical ring resonator sensors are crucial to improve their practical sensing capabilities for biochemical analysis and detection in extremely small detection concentration. We have developed a self-referencing optofluidic ring resonator (SR-OFRR) to vastly improve its sensing capability as a label-free optical biosensor. By monitoring the mode-splitting separation generated on a coupled ring resonator system, the common-mode noise is suppressed by 2 orders of magnitude without any external noise-suppression techniques. In this work, we first carried out theoretical analysis to elucidate the sensing principle and then applied the SR-OFRR biosensor to experimentally detect bovine serum albumin with a concentration detection limit on the order of 1 pg/mL (∼15 fM).