American Chemical Society
mz2c00495_si_001.pdf (26.64 MB)

Self-Assembly of Repetitive Segment and Random Segment Polymer Architectures

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journal contribution
posted on 2022-11-22, 21:44 authored by Hao Yu, Falon C. Kalutantirige, Lehan Yao, Charles M. Schroeder, Qian Chen, Jeffrey S. Moore
Recent advances in chemical synthesis have created new methodologies for synthesizing sequence-controlled synthetic polymers, but rational design of monomer sequence for desired properties remains challenging. In this work, we synthesize periodic polymers with repetitive segments using a sequence-controlled ring-opening metathesis polymerization (ROMP) method, which draws inspiration from proteins containing repetitive sequence motifs. The repetitive segment architecture is shown to dramatically affect the self-assembly behavior of these materials. Our results show that polymers with identical repetitive sequences assemble into uniform spherical nanoparticles after thermal annealing, whereas copolymers with random placement of segments with different sequences exhibit disordered assemblies without a well-defined morphology. Overall, these results bring a new understanding to the role of periodic repetitive sequences in polymer assembly.