jo1c00502_si_001.pdf (45.06 MB)
Self-Assembly of Functionalized Lipophilic Guanosines into Cation-Free Stacked Guanine-Quartets
journal contribution
posted on 2021-07-19, 17:44 authored by Marilena Campitiello, Alessio Cremonini, Marco A. Squillaci, Silvia Pieraccini, Artur Ciesielski, Paolo Samorì, Stefano MasieroThe hierarchical
self-assembly of various lipophilic guanosines
exposing either a phenyl or a ferrocenyl group in the C(8) position
was investigated. In a solution, all the derivatives were found to
self-assemble primarily into isolated guanine (G)-quartets. In spite
of the apparent similar bulkiness of the two substituents, most of
the derivatives form disordered structures in the solid state, whereas
a specific 8-phenyl derivative self-assembles into an unprecedented,
cation-free stacked G-quartet architecture.