Self-Assembling Metallocomplexes of the Amphiphilic
1,4-Diazabicyclo[2.2.2]octane Derivative as a Platform for the Development
of Nonplatinum Anticancer Drugs

Zakharova, Lucia
Ya.; Voloshina, Alexandra D.; Ibatullina, Marina R.; Zhiltsova, Elena P.; Lukashenko, Svetlana S.; Kuznetsova, Darya A.; Kutyreva, Marianna P.; Sapunova, Anastasiia S.; Kufelkina, Anna A.; Kulik, Natalia V.; Kataeva, Olga; Ivshin, Kamil A.; Gubaidullin, Aidar T.; Salnikov, Vadim V.; Nizameev, Irek R.; Kadirov, Marsil K.; Sinyashin, Oleg G.

doi:10.1021/acsomega.1c06465.s001

ao1c06465_si_001.pdf (520.34 kB)

Self-Assembling Metallocomplexes of the Amphiphilic 1,4-Diazabicyclo[2.2.2]octane Derivative as a Platform for the Development of Nonplatinum Anticancer Drugs

journal contribution

posted on 2022-01-14, 14:07 authored by Lucia Ya. Zakharova, Alexandra D. Voloshina, Marina R. Ibatullina, Elena P. Zhiltsova, Svetlana S. Lukashenko, Darya A. Kuznetsova, Marianna P. Kutyreva, Anastasiia S. Sapunova, Anna A. Kufelkina, Natalia V. Kulik, Olga Kataeva, Kamil A. Ivshin, Aidar T. Gubaidullin, Vadim V. Salnikov, Irek R. Nizameev, Marsil K. Kadirov, Oleg G. Sinyashin

New 1-cetyl-4-aza-1-azoniabicyclo[2.2.2]octane bromide complexes with copper(II) bromide and lanthanum(III) nitrate were characterized using dynamic light scattering and transmission electron microscopy, with self-assembly and the morphological behavior elucidated. For the lanthanum(III) nitrate complex, the 3D crystal structure was characterized using X-ray diffractometry. These metallosurfactants were tested as antitumor agents, and a high cytotoxic effect comparable with doxorubicin was revealed against the M-HeLa and A-549 cell lines. Both complexes were 2 times more active toward the MCF-7 cell line than the breast cancer drug tamoxifen. The cytotoxic mechanism of complexes is assumed to be related to the induction of apoptosis through the mitochondrial pathway.