ic0c01777_si_001.pdf (1.78 MB)
Self-Assembled PtII8 Metallosupramolecular Tubular Cage as Dual Warhead Antibacterial Agent in Water
journal contribution
posted on 2020-08-07, 15:33 authored by Soumalya Bhattacharyya, Mangili Venkateswarulu, Jagabandhu Sahoo, Ennio Zangrando, Mrinmoy De, Partha Sarathi MukherjeeDevelopment
of photosensitizer-based self-assembled metallosupramolecular
architectures with important applications is an emerging trend in
supramolecular chemistry. In this study, we report a new benzothiadiazole-based
tetra-pyridyl ligand (L), which upon self-assembly with
a cis-block 90° Pt(II) acceptor generated an
unprecedented tetrafacial Pt(II)8 photoactive tubular molecular
cage (PMB1). This cage could bring an extraordinary photosensitizer,
benzothiadiazole, into water which is otherwise insoluble. PMB1 is fluorescent and shows photogeneration of singlet oxygen in an
aqueous medium. These features make PMB1 a potent antimicrobial
agent in water in both the presence and absence of light. In comparison
to its building blocks and water-soluble alkylated charged ligand
([LMe4][4NO3]), the cage shows much enhanced
photoinduced antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) as a representative of Gram-positive
bacteria and Pseudomonas aeruginosa (PA) as a representative
of Gram-negative bacteria. PMB1 is successful at inactivating
the bacterial growth via both photoactivation of molecular oxygen
and membrane depolarization mechanisms, thus proving to be a dual
warhead. Inactivation of bacteria in water using such a supramolecular
architecture is noteworthy and can shed light on the generation of
new antimicrobial supramolecular systems.