posted on 2021-10-11, 06:44authored byDing Wen, Lile Dong, Kai Li, Yechao Du, Ruiping Deng, Jing Feng, Hongjie Zhang, Daguang Wang
Despite
bismuth-based energy conversion nanomaterials having attracted
extensive attention for nanomedicine, the nanomaterials suffer from
major shortcomings including low tumor accumulation, long internal
retention time, and undesirable photothermal conversion efficiency
(PCE). To combat these challenges, bovine serum albumin and folic
acid co-modified Bi2Se3 nanomedicine with rich
selenium vacancies (abbreviated as VSe-BS) was fabricated
for the second near-infrared (NIR-II) light-triggered photonic hyperthermia.
More importantly, selenium vacancies on the crystal planes (0 1 5)
and (0 1 11) of VSe-BS with similar formation energies
could be distinctively observed via aberration-corrected
scanning transmission electron microscopy images. The defect engineering
endows VSe-BS with enhanced conductivity, making VSe-BS possess outstanding PCE (54.1%) in the NIR-II biowindow
and desirable photoacoustic imaging performance. Tumor ablation studies
indicate that VSe-BS possesses satisfactory therapeutic
outcomes triggered by NIR-II light. These findings give rise to inspiration
for further broadening the biological applications of defect engineering
bismuth-based nanomaterials.