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Selective Synthesis of Isoquinolines by Rhodium(III)-Catalyzed C–H/N–H Functionalization with α‑Substituted Ketones

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journal contribution
posted on 21.07.2016, 00:00 authored by Jie Li, Zhao Zhang, Mengyao Tang, Xiaolei Zhang, Jian Jin
A rhodium­(III)-catalyzed C–H/N–H bond functionalization for the synthesis of 1-aminoisoquinolines from aryl amidines and α-MsO/TsO/Cl ketones was achieved under mild reaction conditions. Thus, this approach provides a practical method for the site-selective synthesis of various synthetically valuable isoquinolines with wide functional group tolerance.