ol6b01916_si_001.pdf (4.74 MB)
Download file

Selective Synthesis of Isoquinolines by Rhodium(III)-Catalyzed C–H/N–H Functionalization with α‑Substituted Ketones

Download (4.74 MB)
journal contribution
posted on 21.07.2016, 00:00 by Jie Li, Zhao Zhang, Mengyao Tang, Xiaolei Zhang, Jian Jin
A rhodium­(III)-catalyzed C–H/N–H bond functionalization for the synthesis of 1-aminoisoquinolines from aryl amidines and α-MsO/TsO/Cl ketones was achieved under mild reaction conditions. Thus, this approach provides a practical method for the site-selective synthesis of various synthetically valuable isoquinolines with wide functional group tolerance.

History