jo0c00722_si_001.pdf (12.46 MB)
Selective N7 Alkylation of 7‑Azaindazoles
journal contributionposted on 2020-05-18, 20:06 authored by Zhiyu Lei, Jianming Bao, Chen Cheng, Wensheng Yu, Bin Hu, Weichen Jin, Salman Jabri, Song Yang, Lianyun Zhao, Christopher J. Sinz, Joseph L. Duffy
A general and mild procedure for alkylation of 7-azaindazoles at the N7 position using alkyl halides in butanone is reported, which requires no additives such as acids or bases. The scope of the reaction regarding substituents on 7-azaindazoles and the alkyl electrophiles is presented.