Selective N7 Alkylation
of 7‑Azaindazoles

Lei, Zhiyu; Bao, Jianming; Cheng, Chen; Yu, Wensheng; Hu, Bin; Jin, Weichen; Jabri, Salman; Yang, Song; Zhao, Lianyun; Sinz, Christopher J.; Duffy, Joseph L.

doi:10.1021/acs.joc.0c00722.s001

jo0c00722_si_001.pdf (12.46 MB)

Selective N7 Alkylation of 7‑Azaindazoles

journal contribution

posted on 2020-05-18, 20:06 authored by Zhiyu Lei, Jianming Bao, Chen Cheng, Wensheng Yu, Bin Hu, Weichen Jin, Salman Jabri, Song Yang, Lianyun Zhao, Christopher J. Sinz, Joseph L. Duffy

A general and mild procedure for alkylation of 7-azaindazoles at the N7 position using alkyl halides in butanone is reported, which requires no additives such as acids or bases. The scope of the reaction regarding substituents on 7-azaindazoles and the alkyl electrophiles is presented.

Selective N7 Alkylation of 7‑Azaindazoles

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