jo0c00722_si_001.pdf (12.46 MB)
Download fileSelective N7 Alkylation of 7‑Azaindazoles
journal contribution
posted on 2020-05-18, 20:06 authored by Zhiyu Lei, Jianming Bao, Chen Cheng, Wensheng Yu, Bin Hu, Weichen Jin, Salman Jabri, Song Yang, Lianyun Zhao, Christopher J. Sinz, Joseph L. DuffyA general
and mild procedure for alkylation of 7-azaindazoles at
the N7 position using alkyl halides in butanone is reported, which
requires no additives such as acids or bases. The scope of the reaction
regarding substituents on 7-azaindazoles and the alkyl electrophiles
is presented.