posted on 2013-12-18, 00:00authored byGanapati D. Yadav, Akhilesh R. Yadav
The present work
deals with synthesis of 2,3-dihydro-1H-1,5-benzodiazepine
from o-phenylenediamine and
acetophenone at 100 °C using a variety of solid acid catalysts,
among which 20% w/w Cs2.5H0.5PW12O40 (Cs-DTP)/K-10 clay was the best. The effects of various
parameters such as speed of agitation, catalyst loading, mole ratio
of 1,2-diamine to acetophenone, and temperature were studied with
20%w/w Cs-DTP/K-10 to establish kinetics of the reaction. The catalyst
was found highly active, robust and reusable. The reaction follows
Langmuir–Hinshelwood–Hougen–Watson type of mechanism
with weak adsorption of all species. The apparent energy of activation
is 9.39 kcal/mol. The studies were extended to synthesis of various
derivatives of benzodiazepines, which are biologically active.