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Selective Formation of Homo- and Heterobivalent Peptidomimetics

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journal contribution
posted on 15.07.2003, 00:00 by Mookda Pattarawarapan, Samuel Reyes, Zebin Xia, Maria C. Zaccaro, H. Uri Saragovi, Kevin Burgess
Methodology is presented for assembling fluorescently labeled bivalent molecules from monovalent constituents, without side chain protection or coupling agents. To illustrate the procedure, a series of bivalent peptidomimetics directed toward the Trk receptors were prepared and screened via fluorescent activated cell sorting scan assays.