Selective Fluorosulfonylation
of Thianthrenium Salts
Enabled by Electrochemistry

Kong, Xianqiang; Chen, Yiyi; Liu, Qianwen; Wang, WenJie; Zhang, Shuangquan; Zhang, Qian; Chen, Xiaohui; Xu, Yuan-Qing; Cao, Zhong-Yan

doi:10.1021/acs.orglett.2c03956.s001

ol2c03956_si_001.pdf (8.64 MB)

Selective Fluorosulfonylation of Thianthrenium Salts Enabled by Electrochemistry

journal contribution

posted on 2023-01-25, 13:41 authored by Xianqiang Kong, Yiyi Chen, Qianwen Liu, WenJie Wang, Shuangquan Zhang, Qian Zhang, Xiaohui Chen, Yuan-Qing Xu, Zhong-Yan Cao

A practical electrochemically driven method for fluorosulfonylation of both aryl and alkyl thianthrenium salts has been disclosed. The strategy does not need external redox reagents or metal catalysts. In combination with C–H thianthrenation of aromatics, this method provides a new tool for the site-selective fluorosulfonylation of drugs.