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Selective C‑5 Oxidative Radical Silylation of Imidazopyridines Promoted by Lewis Acid

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journal contribution
posted on 03.08.2020, 13:08 by Yifan Li, Kaichen Shu, Ping Liu, Peipei Sun
An oxidative cross dehydrogenative coupling of imidazopyridines with silanes was developed using di-tert-butyl peroxide as the oxidant. The coordination effect of Lewis acid was the dominant factor controlling the regioselective addition of silyl radical to imidazopyridines, and the corresponding C-5 silylated imidazo­[1,2-a]­pyridines were obtained in moderate to high yields with a broad substrate scope.