Selective Actinide-Catalyzed Tandem Proton-Transfer Esterification of Aldehydes with Alcohols for the Production of Asymmetric Esters
journal contributionposted on 2017-04-04, 12:19 authored by Heng Liu, Moris S. Eisen
Actinide-catalyzed tandem proton-transfer esterification between aldehydes and alcohols is presented herein for the first time. It represents a novel convenient and external-oxidant-free methodology in the preparation of asymmetric ester compounds. Various kinds of aldehydes and alcohols can be applied to this reaction, affording the corresponding ester product in moderate to high yields. A plausible mechanism was proposed on the basis of the kinetic, stoichiometric, and deuterium-labeling studies.
ester compoundsexternal-oxidant-free methodologyVarious kindsAldehydebasismechanismaldehydeester productAsymmetric Esters Actinide-catalyzed tandem proton-transfer esterificationstoichiometricSelective Actinide-Catalyzed Tandem Proton-Transfer Esterificationdeuterium-labeling studiesyieldpreparation