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Secondary Metabolites from the Chinese Liverwort Cephaloziella kiaeri

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journal contribution
posted on 18.02.2016, 19:27 by Rui-Juan Li, Rong-Xiu Zhu, Yao-Yao Li, Jin-Chuan Zhou, Jiao-Zhen Zhang, Song Wang, Jian-Ping Ye, Yue-Hu Wang, Susan L. Morris-Natschke, Kuo-Hsiung Lee, Hong-Xiang Lou
Sixteen new clerodane diterpenoids, cephaloziellins A–P (116), and two known analogues (17 and 18) were isolated from an EtOH extract of the Chinese liverwort Cephaloziella kiaeri. The structures of the new compounds were elucidated from extensive spectroscopic data (IR, UV, HRESIMS, 1D NMR, and 2D NMR), and the structures of 5, 9, and 15 were confirmed by single-crystal X-ray diffraction analyses. The absolute configurations of all new compounds were established by comparing experimental and calculated electronic circular dichroism spectra.