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Secondary Amine Formation from Reductive Amination of Carbonyl Compounds Promoted by Lewis Acid Using the InCl3/Et3SiH System

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journal contribution
posted on 06.08.2009, 00:00 by On-Yi Lee, Ka-Lun Law, Dan Yang
A robust and reliable method has been developed for reductive amination of primary amines with various aldehydes and ketones using Zn(ClO4)2·6H2O as a catalyst. [In−H] generated in situ via a combination of InCl3 and Et3SiH is employed as an effective reducing system. A variety of secondary amines can be synthesized in a one-pot procedure in excellent yields.